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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Intracranial pressure in childhood cerebral malaria
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 85, No. 3, Year 1991
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Description
Lumbar punctures were performed in 40 Gambian children with acute cerebral malaria aged between 18 months and 10 years. The mean opening pressure was elevated in 32 (80%) of the children, but was not significantly different in the 14 fatal cases compared with survivors: 110 (standard deviation 71) versus 131 (58) mm of cerebrospinal fluid respectively. Cerebral perfusion pressures were also similar in the 2 groups: 64 (20) mm Hg versus 64 (11) mm Hg respectively. There was no clear clinical evidence of raised intracranial pressure, and no evidence of deterioration immediately following lumbar puncture. Nevertheless brain swelling, and consequent brain-stem compression, may contribute to a fatal outcome in cerebral malaria-particularly in those children who die from sudden respiratory arrest. A prospective evaluation of osmotic agents in childhood cerebral malaria seems to be justified. © 1991.
Authors & Co-Authors
Waller, Deborah J.
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Oxford
Nuffield Department of Medicine
Crawley, Jane C.
United Kingdom, Oxford
Nuffield Department of Medicine
Nosten, François Henry
Thailand, Nakhon Pathom
Mahidol University
Chapman, D.
United Kingdom, Oxford
Nuffield Department of Medicine
Krishna, Prof Sanjeev
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Oxford
Nuffield Department of Medicine
Craddock, Charles F.
United Kingdom, Oxford
Nuffield Department of Medicine
Brewster, David R.
Gambia, Banjul
Royal Victoria Teaching Hospital Gambia
Gambia, Banjul
Medical Research Council Laboratories Gambia
White, Nicholas J.
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Oxford
Nuffield Department of Medicine
Statistics
Citations: 66
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/0035-9203(91)90291-6
ISSN:
00359203
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study