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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Safety of pleurodesis with talc poudrage in malignant pleural effusion: a prospective cohort study
Lancet, Volume 369, No. 9572, Year 2007
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Description
Background: Talc is the most effective chemical pleurodesis agent for patients with malignant pleural effusion. However, concerns have arisen about the safety of intrapleural application of talc, after reports of development of acute respiratory distress syndrome in 1-9% of treated patients. Our aim was to establish whether use of large-particle-size talc is safe in patients with malignant pleural effusion. Methods: We did a multicentre, open-label, prospective cohort study of 558 patients with malignant pleural effusion who underwent thoracoscopy and talc poudrage with 4 g of calibrated French large-particle talc in 13 European hospitals, and one in South Africa. The primary endpoint was the occurrence of acute respiratory distress syndrome after talc pleurodesis. Findings: No patients developed acute respiratory distress syndrome (frequency 0%, one-sided 95% CI 0-0·54%). 11 (2%) patients died within 30 days. Additionally, seven patients had non-fatal post-thoracoscopy complications (1·2%), including one case of respiratory failure due to unexplained bilateral pneumothorax. Interpretation: Use of large-particle talc for pleurodesis in malignant pleural effusion is safe, and not associated with the development of acute respiratory distress syndrome. © 2007 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Janssen, Julius P.
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Collier, Gareth
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Astoul, Philippe J.
France, Marseille
Hôpital Sainte Marguerite
Tassi, Gianfranco
Italy, Brescia
Spedali Civili Di Brescia
Noppen, Marc M.P.
Belgium, Jette
Universitair Ziekenhuis Brussel
Rodriǵuez-Panadero, Francisco
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Loddenkemper, Robert
Germany, Berlin
Lungenklinik Heckeshorn
Herth, Felix JF
Germany, Heidelberg
Thoraxklinik am Universitatsklinikum Heidelberg
Gasparini, Stefano
Italy, Ancona
Azienda Ospedaliera Universitaria Ospedali Riuniti, Ancona
Marquette, Charles-Hugo Hugo
France, Lille
Chu Lille
Becke, Birgit
Germany, Bonn
Johanniter-krankenhaus
Froudarakis, M.
Greece, Heraklion
Heraklion University Hospital
Driesen, Peter
Belgium, Turnhout
Sint Elisabethziekenhuis Turnhout
Bolliger, Christoph Thomas
South Africa, Tygerberg
Tygerberg Hospital
Tschopp, Jean Marie
Switzerland, Montana
Centre Valaisan de Pneumologie
Statistics
Citations: 311
Authors: 15
Affiliations: 14
Identifiers
Doi:
10.1016/S0140-6736(07)60708-9
ISSN:
01406736
Research Areas
Cancer
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
South Africa