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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
veterinary
Immunohistochemical and Biochemical Evidence of Ameloblastic Origin of Amyloid-Producing Odontogenic Tumors in Cats
Veterinary Pathology, Volume 50, No. 2, Year 2013
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Description
Amyloid-producing odontogenic tumors (APOT) are rare, and in cats, the histogenesis of the amyloid remains undetermined. In the present study, APOTs in 3 cats were characterized by immunohistochemistry, and the amyloid components analyzed using tandem mass spectrometry. Antiameloblastin antibodies labeled both neoplastic epithelial cells and amyloid in all cases. Neoplastic epithelial cells had strong, diffuse immunoreactivity to antibodies against cytokeratin AE1/AE3, cytokeratin 14, and cytokeratin 19 in all cases and focal immunoreactivity to nerve growth factor receptor antibodies in 2 of 3 cases. Amyloid and some tumor stromal cells were weakly positive for laminin. Calretinin, amelogenin, S100, and glial fibrillary acidic protein antibodies did not label neoplastic epithelial cells or amyloid. Extracted amyloid peptide sequences were compared to the porcine database because the cat genome is not yet complete. Based on this comparison, 1 identical ameloblastin peptide was detected in each tumor. These results suggest that feline APOTs and the amyloid they produce are of ameloblastic lineage. © The Author(s) 2012.
Authors & Co-Authors
Delaney, Martha Ann
United States, Urbana
University of Illinois Urbana-champaign
Singh, Kuldeep
United States, Urbana
University of Illinois Urbana-champaign
Murphy, Charles L.
United States, Knoxville
The University of Tennessee Graduate School of Medicine
Solomon, Alan H.
United States, Knoxville
The University of Tennessee Graduate School of Medicine
Nel, Sulette
South Africa, Pretoria
Faculty of Health Sciences
Boy, Sonja C.
South Africa, Pretoria
Faculty of Health Sciences
Statistics
Citations: 16
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1177/0300985812452583
ISSN:
03009858
e-ISSN:
15442217
Research Areas
Cancer