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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Using a Targeted Proteomics Chip to Explore Pathophysiological Pathways for Incident Diabetes– The Malmö Preventive Project
Scientific Reports, Volume 9, No. 1, Article 272, Year 2019
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Description
Multiplex proteomic platforms provide excellent tools for investigating associations between multiple proteins and disease (e.g., diabetes) with possible prognostic, diagnostic, and therapeutic implications. In this study our aim was to explore novel pathophysiological pathways by examining 92 proteins and their association with incident diabetes in a population-based cohort (146 cases of diabetes versus 880 controls) followed over 8 years. After adjusting for traditional risk factors, we identified seven proteins associated with incident diabetes. Four proteins (Scavenger receptor cysteine rich type 1 protein M130, Fatty acid binding protein 4, Plasminogen activator inhibitor 1 and Insulin-like growth factor-binding protein 2) with a previously established association with incident diabetes and 3 proteins (Cathepsin D, Galectin-4, Paraoxonase type 3) with a novel association with incident diabetes. Galectin-4, with an increased risk of diabetes, and Paraoxonase type 3, with a decreased risk of diabetes, remained significantly associated with incident diabetes after adjusting for plasma glucose, implying a glucose independent association with diabetes. © 2019, The Author(s).
Authors & Co-Authors
Molvin, John
Sweden, Lund
Lunds Universitet
Sweden, Lund
Skånes Universitetssjukhus
Pareek, Manan
Denmark, Holbak
Holbæk Sygehus
United States, Boston
Harvard Medical School
Jujić, Amra
Sweden, Lund
Lunds Universitet
Melander, Olle
Sweden, Lund
Lunds Universitet
Sweden, Lund
Skånes Universitetssjukhus
Råstam, Lennart
Sweden, Lund
Lunds Universitet
Lindblad, Ulf
Sweden, Gothenburg
Göteborgs Universitet
Daka, Bledar
Sweden, Gothenburg
Göteborgs Universitet
Leosdottir, Margret
Sweden, Lund
Lunds Universitet
Sweden, Lund
Skånes Universitetssjukhus
Nilsson, Peter M.
Sweden, Lund
Lunds Universitet
Sweden, Lund
Skånes Universitetssjukhus
Olsen, Michael Hecht
Denmark, Holbak
Holbæk Sygehus
Denmark, Odense
Syddansk Universitet
Magnusson, Martin
Sweden, Lund
Lunds Universitet
Sweden, Lund
Skånes Universitetssjukhus
Statistics
Citations: 24
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1038/s41598-018-36512-y
ISSN:
20452322
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study