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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Chronic lymphoid leukaemia: Clinico-haematological correlation and outcome in a single institution in Niger Delta region of Nigeria
International Journal of Laboratory Hematology, Volume 29, No. 6, Year 2007
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Description
Sixty patients were prospectively studied with the aim of analyzing the clinical and laboratory features and outcome of patients diagnosed with chronic lymphocytic leukaemia (CLL) in a major referral center in Niger Delta region of Nigeria for 10 years (1995-2005). The peripheral blood, bone marrow cytology, clinical features and stage at diagnosis were studied. Treatment modalities, response to treatment and survival outcome of the patients were analysed. Sixty patients (15 men and 45 women) were seen, with female preponderance (M : F ratio,1 : 3). The CLL incidence was 36.4% of total leukaemias. The median age was 56 years with peak age group at 51-60 years while 15% were below 40 years. Major clinical findings include lymphadenopathy (91.7%), anaemia (58.3%), abdominal swelling (58.3%), and splenomegaly (50%) with 53 patients (88.3%) presenting as International (Binet) stage B and C while only seven patients (11.7%) were seen in stage A. The least clinical presentation includes Richter's syndrome in 3.3% of cases and herpes Zoster skin manifestations in two patients (3.3%). There was a strong association between the blood counts at diagnosis and outcome of therapy. The 2-year survival for young (<55 years) and older (>55 years) CLL patients was 27.2% and 28.9%, respectively, which is still very poor because of a number of strong limiting factors. CLL is not rare in Southern Nigeria and its presentations are similar to cases seen worldwide. Contrary to existing literature a female predominance was observed in this study with majority of patients seeking medical intervention late. It is therefore recommended that future research into the genetic make up/HLA typing of patients of African descent is needed to clarify some of the differences observed. © 2007 The Authors.
Authors & Co-Authors
Omoti, C. E.
Nigeria, Benin
University of Benin
Awodu, Omolade Augustina
Nigeria, Benin
University of Benin
Bazuaye, Godwin N.
Nigeria, Benin
University of Benin
Statistics
Citations: 34
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1111/j.1751-553X.2007.00888.x
ISSN:
17515521
e-ISSN:
1751553X
Research Areas
Genetics And Genomics
Study Design
Randomised Control Trial
Cohort Study
Study Locations
Niger
Nigeria
Participants Gender
Male
Female