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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Genital tract inflammation during early HIV-1 infection predicts higher plasma viral load set point in women
Journal of Infectious Diseases, Volume 205, No. 2, Year 2012
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Description
Background. The biggest challenge in human immunodeficiency virus type 1 (HIV-1) prevention in Africa is the high HIV-1 burden in young women. In macaques, proinflammatory cytokine production in the genital tract is necessary for target cell recruitment and establishment of simian immunodeficiency virus (SIV) infection following vaginal inoculation. The purpose of this study was to assess if genital inflammation during early HIV-1 infection predisposes women to rapid disease progression. Methods. Inflammatory cytokine concentrations were measured in cervicovaginal lavage (CVL) from 49 women 6, 17, 30, and 55 weeks after HIV-1 infection and from 22 of these women before infection. Associations between genital inflammation and viral load set point and blood CD4 cell counts 12 months after infection were investigated. Results. Elevated genital cytokine concentrations 6 and 17 weeks after HIV-1 infection were associated with higher viral load set points and, to a lesser extent, with CD4 depletion. CVL cytokine concentrations during early infection did not differ relative to preinfection but were elevated in women who had vaginal discharge, detectable HIV-1 RNA in their genital tracts, and lower blood CD4 counts.Conclusion.Genital inflammation during early HIV-1 infection was associated with higher viral load set point and CD4 depletion, which are markers of rapid disease progression. Strategies aimed at reducing genital inflammation during early HIV-1 infection may slow disease progression. © 2011 The Author.
Authors & Co-Authors
Masson, Lindi
South Africa, Cape Town
Faculty of Health Sciences
Passmore, Jo Ann Shelley
South Africa, Cape Town
Faculty of Health Sciences
South Africa, Johannesburg
National Health Laboratory Service
Mlisana, Koleka P.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Williamson, Carolyn
South Africa, Cape Town
Faculty of Health Sciences
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Little, Francesca
South Africa, Cape Town
University of Cape Town
Bebell, Lisa M.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Columbia University
United States, San Francisco
University of California, San Francisco
Walzl, Gerhard
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Rose-Abrahams, Melissa
South Africa, Cape Town
Faculty of Health Sciences
Woodman, Zenda L.
South Africa, Cape Town
University of Cape Town
Abdool Karim, Quarraisha Abdool
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Columbia University
Abdool Karim, Salim S.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Columbia University
Statistics
Citations: 78
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1093/infdis/jir715
ISSN:
00221899
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Participants Gender
Female