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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Assessing the potency of oral polio vaccine kept outside of the cold chain during a national immunization campaign in Chad
Vaccine, Volume 29, No. 34, Year 2011
Notification
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Description
This study is the first systematic documentation of the potency of monovalent oral polio vaccine type 3 (mOPV3) kept at ambient temperatures during a polio immunization campaign in Chad. During the study test vials were exposed to temperatures of up to 47.1°C, and kept outside of the 2-8°C range for a maximum of 86.9. hours. Post-campaign laboratory testing confirmed that the test vials were still potent, and in conformity with the defined release specifications. Further, the Vaccine Vial Monitors performed as expected, giving an early warning indication of when cumulative exposure to heat reached levels that may have negatively affected the vaccine's potency. This study provides proof-of-concept evidence that certain types of OPV remain potent and thus can be kept, for limited periods of time, as well as administered at ambient temperatures. © 2011 Elsevier Ltd.
Authors & Co-Authors
Zipursky, Simona
France, Ferney-voltaire
Path
Boualam, Liliane
Switzerland, Geneva
Organisation Mondiale de la Santé
Cheikh, Dah Ould
Switzerland, Geneva
Organisation Mondiale de la Santé
Fournier-Caruana, Jacqueline
Switzerland, Geneva
Organisation Mondiale de la Santé
Hamid, Djabar
Chad
Ministry of Health
Janssen, Mathias
Belgium, Brussels
Scientific Institute of Public Health, Brussels
Kartoglu, Umit
Switzerland, Geneva
Organisation Mondiale de la Santé
Waeterloos, Genevieve
Belgium, Brussels
Scientific Institute of Public Health, Brussels
Ronveaux, Olivier
Switzerland, Geneva
Organisation Mondiale de la Santé
Statistics
Citations: 22
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.vaccine.2011.06.011
ISSN:
0264410X
e-ISSN:
18732518
Research Areas
Health System And Policy
Maternal And Child Health
Study Locations
Chad