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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Serum lipid profiles and homocysteine levels in adults with stroke or myocardial infarction in the town of Gombe in Northern Nigeria
Journal of Health, Population and Nutrition, Volume 22, No. 4, Year 2004
Notification
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Description
While the incidence of infectious diseases has been on the decline in developing countries, the toll of cardiovascular diseases, including stroke and myocardial infarction, has been increasing. The impression of physicians in certain regions of the western Sahel, including the state of Gombe in northeastern Nigeria, is that macrovascular disease in the indigenous population is on the rise. This study was, therefore, undertaken to compare well-established risk factors for cardiovascular disease in a group of 53 men (n=34) and women (n=19) in the town of Gombe who had suffered a stroke or heart attack with the corresponding parameters in 48 age- and gender-matched healthy adults living in the same environment. The parameters of cardiovascular diseases considered were: overweight and obesity, blood pressure, lipid profiles, and homocysteine. While the male and female patients who had suffered stroke (n=48) or heart attack (n=5) were borderline hypertensive, their mean body mass index values were not different from the corresponding values of their control groups. Although the serum homocysteine levels of the patients and controls were not significantly different, 85% of the stroke patients had serum homocysteine levels greater than 10 μM. These high homocysteine levels could not be accounted for by sub-optimal folate or vitamin B12 status. The serum levels of HDL-cholesterol and triglyceride were not significantly different between the male and female patients and their respective controls. However, the males, but not the females, with macrovascular disease had significantly higher levels of total cholesterol (161 vs 137 mg/dL, p=0.04) and LDL-cholesterol (91 vs 70 mg/dL, p=0.02). In addition, both female and male stroke/myocardial infarction patients exhibited an elevated LDL-cholesterol/HDL-cholesterol ratio. These results indicate that blood pressure and the LDL-cholesterol/HDL-cholesterol ratio are associated with stroke and myocardial infarction in adults in northern Nigeria, thereby creating potential opportunities for possible public-health interventions. © 2004 ICDDR,B: Centre for Health and Population Research.
Authors & Co-Authors
Glew, Robert Hayes
United States, Albuquerque
Unm School of Medicine
Okolie, Henry I.
Nigeria
Federal Medical Centre Nigeria
Crossey, Michael J.
United States, Albuquerque
Tricore Reference Laboratories
Suberu, Ojo
Nigeria
Federal Medical Centre Nigeria
Trujillo, Miguel R.
United States, Albuquerque
Unm School of Medicine
Pereyra, Mario
United States, Albuquerque
Unm School of Medicine
VanderJagt, Dorothy Joan
United States, Albuquerque
Unm School of Medicine
Statistics
Citations: 7
Authors: 7
Affiliations: 3
Identifiers
ISSN:
16060997
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Nigeria
Participants Gender
Male
Female