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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
IL-25 regulates Th17 function in autoimmune inflammation
Journal of Experimental Medicine, Volume 204, No. 1, Year 2007
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Description
Interleukin (IL)-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. We now show that IL-25 also regulates the development of autoimmune inflammation mediated by IL-17-producing T cells. We have generated IL-25-deficient (il25-/-) mice and found that they are highly susceptible to experimental autoimmune encephalomyelitis (EAE). The accelerated disease in the il25-/- mice is associated with an increase of IL-23 in the periphery and a subsequent increase in the number of inflammatory IL-17-, IFNγ-, and TNF-producing T cells that invade the central nervous system. Neutralization of IL-17 but not IFNγ in il25-/- mice prevented EAE, suggesting that IL-17 is a major disease-promoting factor. IL-25 treatment at several time points during a relapse-remitting model or chronic model of EAE completely suppressed disease. IL-25 treatment induced elevated production of IL-13, which is required for suppression of Th17 responses by direct inhibition of IL-23, IL-1β, and IL-6 expression in activated dendritic cells. Thus, IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity. JEM © The Rockefeller University Press.
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Authors & Co-Authors
Kleinschek, Melanie A.
United States, Palo Alto
Discovery Research
Owyang, Alexander M.
United States, Palo Alto
Discovery Research
Joyce-Shaikh, Barbara
United States, Palo Alto
Discovery Research
Langrish, Claire L.
United States, Palo Alto
Discovery Research
United States, Palo Alto
Roche Palo Alto
Chen, Yi
United States, Palo Alto
Discovery Research
Gorman, Daniel M.
United States, Palo Alto
Discovery Research
Blumenschein, Wendy M.
United States, Palo Alto
Experimental Pathology and Pharmacology
McClanahan, Terrill
United States, Palo Alto
Experimental Pathology and Pharmacology
Brombacher, Frank
South Africa, Cape Town
University of Cape Town
Hurst, Stephen D.
United States, Palo Alto
Discovery Research
United States, San Francisco
Genentech, Inc
Kastelein, Robert A.
United States, Palo Alto
Discovery Research
Cua, Daniel J.
United States, Palo Alto
Discovery Research
Statistics
Citations: 407
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1084/jem.20061738
ISSN:
00221007
e-ISSN:
00221007