Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Birth defects among a cohort of infants born to HIV-infected women on antiretroviral medication
Journal of Perinatal Medicine, Volume 39, No. 2, Year 2011
Notification
URL copied to clipboard!
Description
Objective: To determine rate of and risk factors for birth defects in infants born to HIV-infected women receiving nucleoside and protease inhibitor antiretroviral (ARV) therapy. Methods: Birth defects were evaluated among infants on the Pediatric AIDS Clinical Trials Group 316 trial that studied addition of peripartum nevirapine to established ARV regimen for prevention of mother-to-child transmission. Maternal therapy was categorized by trimester of earliest exposure. Birth defects were coded using conventions of the Antiretroviral Pregnancy Registry. Results: Birth defects were detected in 60/1414 (4.2%; 95% CI 3.3-5.4%) infants including 30/636 (4.7%; 95% CI 3.2-6.7%) with first trimester ARV exposure and 30/778 (3.9%; 95% CI 2.6-5.5%) with exposure only after the first trimester (P=0.51). Rates of classes of defects were similar between first trimester compared to later exposure groups except heart defects which occurred in 16 (2.5%; 95% CI 1.4-4.1%) with first trimester ARV exposure and in six (0.8%; 95% CI 0.3-1.7%) infants with later exposure (P=0.02). Exposure to ARV was not associated with specific types of heart defects. Two cases of cardiomyopathy were noted. Conclusion: ARV use in early pregnancy was not associated with an increased risk of birth defects overall. The possible association of ARV exposure with heart defects requires further surveillance. © 2011 by Walter de Gruyter Berlin New York.
Authors & Co-Authors
Watts, Diane Heather
Unknown Affiliation
Huang, Sharon
Unknown Affiliation
Culnane, M.
Unknown Affiliation
Kaiser, Kathleen A.
Unknown Affiliation
Scheuerle, Angela
Unknown Affiliation
Mofenson, Lynne M.
Unknown Affiliation
Stanley, Kenneth
Unknown Affiliation
Newell, Marie Louise
Unknown Affiliation
Mandelbrot, Laurent
Unknown Affiliation
Delfraissy, Jean François
Unknown Affiliation
Cunningham, Coleen K.
Unknown Affiliation
Statistics
Citations: 49
Authors: 11
Affiliations: 11
Identifiers
Doi:
10.1515/JPM.2010.139
ISSN:
03005577
e-ISSN:
16193997
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female