Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
A Comparison of Brain Gene Expression Levels in Domesticated and Wild Animals
PLoS Genetics, Volume 8, No. 9, Article e1002962, Year 2012
Notification
URL copied to clipboard!
Description
Domestication has led to similar changes in morphology and behavior in several animal species, raising the question whether similarities between different domestication events also exist at the molecular level. We used mRNA sequencing to analyze genome-wide gene expression patterns in brain frontal cortex in three pairs of domesticated and wild species (dogs and wolves, pigs and wild boars, and domesticated and wild rabbits). We compared the expression differences with those between domesticated guinea pigs and a distant wild relative (Cavia aperea) as well as between two lines of rats selected for tameness or aggression towards humans. There were few gene expression differences between domesticated and wild dogs, pigs, and rabbits (30-75 genes (less than 1%) of expressed genes were differentially expressed), while guinea pigs and C. aperea differed more strongly. Almost no overlap was found between the genes with differential expression in the different domestication events. In addition, joint analyses of all domesticated and wild samples provided only suggestive evidence for the existence of a small group of genes that changed their expression in a similar fashion in different domesticated species. The most extreme of these shared expression changes include up-regulation in domesticates of SOX6 and PROM1, two modulators of brain development. There was almost no overlap between gene expression in domesticated animals and the tame and aggressive rats. However, two of the genes with the strongest expression differences between the rats (DLL3 and DHDH) were located in a genomic region associated with tameness and aggression, suggesting a role in influencing tameness. In summary, the majority of brain gene expression changes in domesticated animals are specific to the given domestication event, suggesting that the causative variants of behavioral domestication traits may likewise be different. © 2012 Albert et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s001.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s002.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s003.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s004.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s005.zip
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s006.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s007.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s008.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s009.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s010.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s011.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s012.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s013.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s014.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3459979/bin/pgen.1002962.s015.docx
Authors & Co-Authors
Albert, Frank W.
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
United States, Princeton
Princeton University
Somel, Mehmet
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Germany, Munich
Administrative Headquarters of the Max Planck Society
Carneiro, Miguel
Portugal, Fornelo e Vairao
Cibio - Centro de Investigação em Biodiversidade e Recursos Genéticos
Portugal, Porto
Universidade do Porto
Aximu-Petri, Ayinuer
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Halbwax, Michel
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Gabon
Fernan Vaz Gorilla Project
Thalmann, Olaf
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Finland, Turku
Turun Yliopisto
Blanco-Aguiar, Jose A.
Portugal, Fornelo e Vairao
Cibio - Centro de Investigação em Biodiversidade e Recursos Genéticos
Portugal, Porto
Universidade do Porto
Spain, Ciudad Real
Csic-uclm - Instituto de Investigacion en Recursos Cinegeticos Irec
Plyusnina, Irina Z.
Russian Federation, Novosibirsk
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Trut, Lyudmíla N.
Russian Federation, Novosibirsk
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Villafuerte, Rafael
Spain, Ciudad Real
Csic-uclm - Instituto de Investigacion en Recursos Cinegeticos Irec
Ferrand, Nuno M.
Portugal, Fornelo e Vairao
Cibio - Centro de Investigação em Biodiversidade e Recursos Genéticos
Portugal, Porto
Universidade do Porto
Kaiser, Sylvia
Germany, Munster
University of Münster
Jensen, Per
Sweden, Linkoping
Linköpings Universitet
Pääbo, Svante
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Statistics
Citations: 126
Authors: 14
Affiliations: 11
Identifiers
Doi:
10.1371/journal.pgen.1002962
e-ISSN:
15537404
Research Areas
Genetics And Genomics
Study Locations
Guinea