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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Evolution of proviral gp120 over the first year of HIV-1 subtype C infection
Virology, Volume 383, No. 1, Year 2009
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Description
The evolution of proviral gp120 during the first year after seroconversion in HIV-1 subtype C infection was addressed in a case series of eight subjects. Multiple viral variants were found in two out of eight cases. Slow rate of viral RNA decline and high early viral RNA set point were associated with a higher level of proviral diversity from 0 to 200 days after seroconversion. Proviral divergence from MRCA over the same period also differed between subjects with slow and fast decline of viral RNA, suggesting that evolution of proviral gp120 early in infection may be linked to the level of viral RNA replication. Changes in the length of variable loops were minimal, and length reduction was more common than length increase. Potential N-linked glycosylation sites ranged ± one site, showing common fluctuations in the V4 and V5 loops. These results highlight the role of proviral gp120 diversity and diversification in the pathogenesis of acute HIV-1 subtype C infection. © 2008 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Novitsky, Vladimir A.
United States, Boston
Harvard T.h. Chan School of Public Health
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Lagakos, Stephen W.
United States, Boston
Harvard T.h. Chan School of Public Health
Herzig, Michaela
United States, Boston
Harvard T.h. Chan School of Public Health
Bonney, Caitlin
United States, Boston
Harvard T.h. Chan School of Public Health
Kebaabetswe, Lemme Prica
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Rossenkhan, Raabya
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Nkwe, David O.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Margolin, Lauren
United States, Boston
Harvard T.h. Chan School of Public Health
Musonda, Rosemary Mubanga
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Moyo, Sikhulile M.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Woldegabriel, Elias
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
van Widenfelt, Erik
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Makhema, Joseph M.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Essex, Max E.
United States, Boston
Harvard T.h. Chan School of Public Health
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Statistics
Citations: 39
Authors: 14
Affiliations: 2
Identifiers
Doi:
10.1016/j.virol.2008.09.017
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Infectious Diseases