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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Resistance to first-line tuberculosis drugs in three cities of Nigeria
Tropical Medicine and International Health, Volume 16, No. 8, Year 2011
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Description
Objectives To determine the levels of resistance to first-line tuberculosis drugs in three cities in three geopolitical zones in Nigeria. Methods A total of 527 smear-positive sputum samples from Abuja, Ibadan and Nnewi were cultured on BACTEC- MGIT 960. Drug susceptibility tests (DST) for streptomycin, isoniazid, rifampicin and ethambutol were performed on 428 culture-positive samples on BACTEC-MGIT960. Results Eight per cent of the specimens cultured were multi-drug-resistant Mycobacterium tuberculosis (MDR-TB) with varying levels of resistance to individual and multiple first-line drugs. MDR was strongly associated with previous treatment: 5% of new and 19% of previously treated patients had MDR-TB (OR 4.1 (95% CI 1.9-8.8), P=0.001) and with young adult age: 63% of patients with and 38% without MDR-TB were 25-34years old (P=0.01). HIV status was documented in 71%. There was no association between MDR-TB and HIV coinfection (P=0.9) and gender (P>0.2 for both). Conclusions MDR-TB is an emerging problem in Nigeria. Developing good quality drug susceptibility test facilities, routine monitoring of drug susceptibility and improved health systems for the delivery of and adherence to first- and second-line treatment are imperative to solve this problem. © 2011 Blackwell Publishing Ltd.
Authors & Co-Authors
Lawson, L. L.O.
Nigeria, Abuja
Zankli Medical Centre
Yassin, Mohammed Ahmed
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Abdurrahman, Saddiq Tsimiri
Nigeria, Abuja
National Tuberculosis and Leprosy Control Programme
Parry, Christopher Mark
Cambodia, Siem Reap
Angkor Hospital for Children
Dacombe, Russell J.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Sogaolu, Olumide M.
Nigeria, Ibadan
University College Hospital, Ibadan
Ebisike, Juliana N.
Nigeria, Abuja
Wuse General Hospital
Uzoewulu, Gertrude N.
Nigeria, Nnewi
Nnamdi Azikiwe Teaching Hospital
Lawson, L. O.
Nigeria, Abuja
Zankli Medical Centre
Emenyonu, Nnamdi E.
Nigeria, Abuja
Zankli Medical Centre
Ouoha, J. O.
Nigeria, Abuja
Zankli Medical Centre
David, J. S.
Nigeria, Abuja
National Tuberculosis and Leprosy Control Programme
Davies, Peter D.O.
Cambodia, Siem Reap
Angkor Hospital for Children
Eduardo Cuevas, Luis Eduardo
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Statistics
Citations: 32
Authors: 14
Affiliations: 7
Identifiers
Doi:
10.1111/j.1365-3156.2011.02792.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Infectious Diseases
Study Locations
Nigeria