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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mucocutaneous criteria for the diagnosis of Behçet's disease: An analysis of clinicopathologic data from multiple international centers
Journal of the American Academy of Dermatology, Volume 32, No. 6, Year 1995
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Description
Background: Although four of five of the new international criteria for the diagnosis of Behçet's disease relate to mucocutaneous lesions, disagreement exists as to the exact nature of cutaneous lesions (e.g., vessel-based vs follicular). Objective: Our purpose was to review clinical data, clinical photographs, and skin biopsy specimens from multiple medical centers throughout the world to monitor current practice in the implementation of mucocutaneous diagnostic criteria for Behçet's disease. Methods: Ten medical centers responded to a request to collaborate by sending clinical data, photographs of cutaneous lesions, and biopsy specimens from 22 patients. Results: Of specimens from 22 patients, 14 revealed a histopathologic pattern of neutrophils containing perivascular and interstitial inflammation, whereas specimens from three patients revealed only mononuclear cells in a vessel-based pattern. Biopsy specimens from three patients revealed primarily folliculocentric inflammation and an additional two specimens were from erythema nodosum-like lesions. Conclusion: Perivascular inflammation was the predominant histopathologic finding in specimens of cutaneous lesions in this clinical series. Folliculocentric lesions could not be predicted on the basis of review of clinical photographs. Histopathologic assessment of cutaneous lesions is crucial if the proposal is accepted that exclusion of folliculocentric lesions is important to ensure accurate implementation of diagnostic criteria in patients with suspected Behçet's disease. © 1995.
Authors & Co-Authors
Jorizzo, Joseph L.
United States, Winston Salem
Wake Forest University School of Medicine
Abernethy, John L.
United States, Winston Salem
Wake Forest University School of Medicine
White, Wain L.
United States, Winston Salem
Wake Forest University School of Medicine
Mangelsdorf, Heidi C.
United States, Winston Salem
Wake Forest University School of Medicine
Zouboulis, Christos C.
Germany, Berlin
Freie Universität Berlin
Sarica, Rifkiye
Turkey, Istanbul
İstanbul Tıp Fakültesi
Gaffney, Karl
United Kingdom, London
The Royal London Hospital
Mat, Cem
Turkey, Istanbul
Istanbul Üniversitesi
Yazici, H.
Turkey, Istanbul
Istanbul Üniversitesi
Ialaan, Abdullah Al
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Assad-Khalil, Samir Helmy
Egypt, Alexandria
Faculty of Medicine
Kaneko, Fumio
Japan, Fukushima
Fukushima Medical University
Frederick Jorizzo, Ernest A.
Unknown Affiliation
Statistics
Citations: 109
Authors: 13
Affiliations: 8
Identifiers
Doi:
10.1016/0190-9622(95)91333-5
ISSN:
01909622