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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The proportion of asymptomatic infections and spectrum of disease among pregnant women infected by Zika virus: Systematic monitoring in French Guiana, 2016
Eurosurveillance, Volume 22, No. 44, Article 17-00102, Year 2017
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Description
Zika virus (ZIKV) infection has been associated with complications during pregnancy. Although the presence of symptoms might be a risk factor for complication, the proportion of ZIKV-infected pregnant women with symptoms remains unknown. Following the emergence of ZIKV in French Guiana, all pregnancies in the territory were monitored by RT-PCR and/or detection of ZIKV antibodies. Follow-up data collected during pregnancy monitoring interviews were analysed from 1 February to 1 June 2016. We enrolled 3,050 pregnant women aged 14–48 years and 573 (19%) had laboratory-confirmed ZIKV infection. Rash, arthralgia, myalgia and conjunctival hyperaemia were more frequently observed in ZIKV-positive women; 23% of them (95% confidence interval (CI): 20–27) had at least one symptom compatible with ZIKV infection. Women 30 years and older were significantly more likely to have symptoms than younger women (28% vs 20%). The proportion of symptomatic infections varied from 17% in the remote interior to 35% in the urbanised population near the coast (adjusted risk ratio: 1.6; 95% CI: 1.4–1.9.). These estimates put findings on cohorts of symptomatic ZIKV-positive pregnant women into the wider context of an epidemic with mainly asymptomatic infections. The proportion of symptomatic ZIKV infections appears to vary substantially between populations. © The Authors, 2017.
Authors & Co-Authors
Fritzell, Camille
French Guiana, Cayenne
Institut Pasteur de la Guyane
Mathéus, Séverine
French Guiana, Cayenne
Institut Pasteur de la Guyane
Adde, Antoine
French Guiana, Cayenne
Institut Pasteur de la Guyane
Demar, Magalie Pierre
French Guiana, Cayenne
Centre Hospitalier Andree Rosemon
Kazanji, Mirdad
French Guiana, Cayenne
Institut Pasteur de la Guyane
Cauchemez, Simon
France, Paris
Institut Pasteur, Paris
France, Paris
Cnrs Centre National de la Recherche Scientifique
Rousset, Dominique
French Guiana, Cayenne
Institut Pasteur de la Guyane
Statistics
Citations: 39
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.2807/1560-7917.ES.2017.22.44.17-00102
ISSN:
1025496X
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female