Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Physical mapping of the elephant X chromosome: Conservation of gene order over 105 million years
Chromosome Research, Volume 17, No. 7, Year 2009
Notification
URL copied to clipboard!
Description
All therian mammals (eutherians and marsupials) have an XX female/XY male sex chromosome system or some variant of it. The X and Y evolved from a homologous pair of autosomes over the 166 million years since therian mammals diverged from monotremes. Comparing the sex chromosomes of eutherians and marsupials defined an ancient X conserved region that is shared between species of these mammalian clades. However, the eutherian X (and the Y) was augmented by a recent addition (XAR) that is autosomal in marsupials. XAR is part of the X in primates, rodents, and artiodactyls (which belong to the eutherian clade Boreoeutheria), but it is uncertain whether XAR is part of the X chromosome in more distantly related eutherian mammals. Here we report on the gene content and order on the X of the elephant (Loxodonta africana)-a representative of Afrotheria, a basal endemic clade of African mammals-and compare these findings to those of other documented eutherian species. A total of 17 genes were mapped to the elephant X chromosome. Our results support the hypothesis that the eutherian X and Y chromosomes were augmented by the addition of autosomal material prior to eutherian radiation. Not only does the elephant X bear the same suite of genes as other eutherian X chromosomes, but gene order appears to have been maintained across 105 million years of evolution, perhaps reflecting strong constraints posed by the eutherian X inactivation system. © 2009 Springer Science+Business Media B.V.
Authors & Co-Authors
Rodríguez Delgado, Claudia Leticia
Australia, Canberra
Anu Research School of Biology
Mexico, Cuernavaca
Universidad Nacional Autónoma de México Campus Morelos
Waters, Paul D.
Australia, Canberra
Anu Research School of Biology
Gilbert, Clément
South Africa, Stellenbosch
Stellenbosch University
United States, Arlington
The University of Texas at Arlington
Robinson, Terence J.
South Africa, Stellenbosch
Stellenbosch University
Graves, Jennifer A.Marshall
Australia, Canberra
Anu Research School of Biology
Statistics
Citations: 69
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1007/s10577-009-9079-1
ISSN:
09673849
e-ISSN:
15736849
Research Areas
Cancer
Genetics And Genomics
Participants Gender
Male
Female