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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Treatment of Plasmodium falciparum malaria with pyrimethamine-sulfadoxine: Selectivepressure for resistance is a function of long elimination half-life
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 87, No. 1, Year 1993
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Description
In an area of continuing transmission of Plasmodium falciparum on the Kenya coast, children treated with pyrimethamine-sulfadoxine experienced rapid parasite clearance, although a high proportion became reinfected within a short time. The frequency of pyrimethamine resistance in vitro in new infections was higher during the elimination phase of drug from a previous treatment. In infections which occurred at times when predicted residual drug concentrations were no longer inhibitory, incidence of pyrimethamine resistance was no different from the natural or background frequency. These results are discussed in terms of the selective pressure for resistance which is exerted by drugs with long elimination half-lives and a consideration of possible ways by which the problem might be addressed. © 1993 Oxford University Press.
Authors & Co-Authors
Watkins, W. M.
Kenya, Nairobi
Kenya Medical Research Institute
Mosobo, Moses
Kenya, Nairobi
Kenya Medical Research Institute
Watkins, Williams M.
United Kingdom, Liverpool
University of Liverpool
Statistics
Citations: 223
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/0035-9203(93)90431-O
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Kenya