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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registry
European Journal of Heart Failure, Volume 23, No. 12, Year 2021
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Description
Aims: Hypertensive disorders occur in women with peripartum cardiomyopathy (PPCM). How often hypertensive disorders co-exist, and to what extent they impact outcomes, is less clear. We describe differences in phenotype and outcomes in women with PPCM with and without hypertensive disorders during pregnancy. Methods and results: The European Society of Cardiology EURObservational Research Programme PPCM Registry enrolled women with PPCM from 2012–2018. Three groups were examined: (i) women without hypertension (PPCM-noHTN); (ii) women with hypertension but without pre-eclampsia (PPCM-HTN); (iii) women with pre-eclampsia (PPCM-PE). Maternal (6-month) and neonatal outcomes were compared. Of 735 women included, 452 (61.5%) had PPCM-noHTN, 99 (13.5%) had PPCM-HTN and 184 (25.0%) had PPCM-PE. Compared to women with PPCM-noHTN, women with PPCM-PE had more severe symptoms (New York Heart Association class IV in 44.4% vs. 29.9%, P < 0.001), more frequent signs of heart failure (pulmonary rales in 70.7% vs. 55.4%, P = 0.002), a higher baseline left ventricular ejection fraction (LVEF) (32.7% vs. 30.7%, P = 0.005) and a smaller left ventricular end-diastolic diameter (57.4 ± 6.7 mm vs. 59.8 ± 8.1 mm, P = 0.001). There were no differences in the frequencies of death from any cause, rehospitalization for any cause, stroke, or thromboembolic events. Compared to women with PPCM-noHTN, women with PPCM-PE had a greater likelihood of left ventricular recovery (LVEF ≥ 50%) (adjusted odds ratio 2.08, 95% confidence interval 1.21–3.57) and an adverse neonatal outcome (composite of termination, miscarriage, low birth weight or neonatal death) (adjusted odds ratio 2.84, 95% confidence interval 1.66–4.87). Conclusion: Differences exist in phenotype, recovery of cardiac function and neonatal outcomes according to hypertensive status in women with PPCM. © 2021 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9311416/bin/EJHF-23-2058-s001.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC9311416/bin/EJHF-23-2058-s003.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC9311416/bin/EJHF-23-2058-s002.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC9311416/bin/EJHF-23-2058-s004.docx
Authors & Co-Authors
Jackson, Alice M.
United Kingdom, Glasgow
University of Glasgow
Frogoudaki, Alexandra A.
Greece, Athens
Attikon University Hospital
Laroche, Cécile
France, Sophia Antipolis
Eorp
Gustafsson, Finn
Denmark, Copenhagen
Rigshospitalet
Ibrahim, Bassem S.S.
United Kingdom, Carlisle
North Cumbria Integrated Care Nhs Foundation Trust
Mebazaa, Alexandre
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Johnson, Mark Richard
United Kingdom, London
Imperial College London School of Medicine
Seferović, Petar M.
Serbia, Belgrade
Institute for the Serbian Language of Sasa
Regitz-Zagrosek, Vera
Germany, Berlin
Charité – Universitätsmedizin Berlin
Mbakwem, Amam
Nigeria, Lagos
University of Lagos
Böhm, Michael
Germany, Homburg
Universitätsklinikum Des Saarlandes Medizinische Fakultät Der Universität Des Saarlandes
Prameswari, Hawani Sasmaya
Indonesia, Bandung
Universitas Padjadjaran
Fouad, Doaa A.
Egypt, Asyut
Assiut University
Goland, Sorel
Israel, Rehovot
Kaplan Medical Center
Damasceno, A. Antonio Moura
Mozambique, Maputo
Universidade Eduardo Mondlane
Karaye, Kamilu Musa
Nigeria, Kano
Bayero University
Farhan, Hasan Ali
Iraq, Baghdad
Ministry of Higher Education and Scientific Research, Iraq
Hamdan, Righab H.
Lebanon, Beirut
Beirut Cardiac Institute
Maggioni, Aldo Pietro
France, Sophia Antipolis
Eorp
Sliwa, Karen S.
South Africa, Cape Town
University of Cape Town
Bauersachs, Johann
Germany, Hannover
Hannover Medical School
van der Meer, Peter
Netherlands, Groningen
Rijksuniversiteit Groningen
Statistics
Citations: 17
Authors: 22
Affiliations: 22
Identifiers
Doi:
10.1002/ejhf.2264
ISSN:
13889842
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Case-Control Study
Participants Gender
Female