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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Silent brain infarcts are rare in Kuwaiti children with sickle cell disease and high Hb F
American Journal of Hematology, Volume 70, No. 3, Year 2002
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Description
Overt stroke is rare among sickle cell disease (SCD) patients in Kuwait. However, there are no previous studies of silent cerebral infarcts, which have been described in up to 20% of American children with Hb SS. We have carried out a prospective brain MRI study among otherwise normal SCD patients, who were consecutive patients seen in a 1-year period to document the prevalence of silent cerebral infarcts in children with sickle cell disease in Kuwait. Any patient with a previous seizure or other neurological abnormality was excluded. MRI was done with a 1.5 Tesla unit with super-conducting magnet. T1- and T2-weighted sagittal and axial sections and proton density axial images were obtained in 5-mm thick sections. The study group consisted of 30 (23 SS and 7 Sβ0Thal) patients-19 males and 11 females-whose ages ranged from 6 to 17 (mean of 9.8 ± 3.5) years. Hb F ranged from 11% to 35% with a mean of 22.8% ± 5.7%. Only one patient, a 10-and-a-half-year-old boy with Hb SS, showed hyperintense signals in the parietal white matter, consistent with small infarcts, thus giving a prevalence of 3.3%. Silent brain infarcts are uncommon in our patients, and the protective factors remain to be fully elucidated. © 2002 Wiley-Liss, Inc.
Authors & Co-Authors
Adekile, Adekunle D.
Kuwait, Kuwait City
Kuwait University
Yacoub, F. M.
Kuwait, Safat
Mubarak Al-kabeer Hospital
Gupta, Renu K.
Kuwait, Kuwait City
Kuwait University
Sinan, Tariq S.
Kuwait, Kuwait City
Kuwait University
Haider, Mohammad Zafaryab
Kuwait, Kuwait City
Kuwait University
Habeeb, Yousif Kassim R.
Kuwait, Safat
Mubarak Al-kabeer Hospital
Al-Bloushi, Maliha Askar Soud
Kuwait, Safat
Mubarak Al-kabeer Hospital
Moosa, Allie
Kuwait, Kuwait City
Kuwait University
Statistics
Citations: 37
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1002/ajh.10143
ISSN:
03618609
Research Areas
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male
Female