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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Golestan cohort study of oesophageal cancer: Feasibility and first results
British Journal of Cancer, Volume 92, No. 1, Year 2005
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Description
To investigate the incidence of oesophageal cancer (EC) in the Golestan province of North-East Iran, we invited 1349 rural and urban inhabitants of Golestan province aged 35-80 to undergo extensive lifestyle interviews and to provide biological samples. The interview was repeated on a subset of 130 participants to assess reliability of questionnaire and medical information. Temperature at which tea was consumed was measured on two occasions by 110 subjects. Samples of rice, wheat and sorghum were tested for fumonisin contamination. An active follow-up was carried out after 6 and 12 months. A total of 1057 subjects (610 women and 447 men) participated in this feasibility study (78.4% participation rate). Cigarette smoking, opium and alcohol use were reported by 163 (13.8%), 93 (8.8%) and 39 (3.7%) subjects, respectively. Tobacco smoking was correlated with urinary cotinine (κ = 0.74). Most questionnaire data had κ > 0.7 in repeat measurements; tea temperature measurement was reliable (κ = 0.71). No fumonisins were detected in the samples analysed. During the follow-up six subjects were lost (0.6%), two subjects developed EC (one dead, one alive); in all, 13 subjects died (with cause of death known for 11, 84.6%). Conducting a cohort study in Golestan is feasible with reliable information obtained for suspected risk factors; participants can be followed up for EC incidence and mortality. © 2005 Cancer Research UK.
Authors & Co-Authors
Pourshams, Akram
Iran, Tehran
Digestive Diseases Research Center
Saadatian, Mohammad
France, Lyon
Centre International de Recherche Sur le Cancer
Nouraie, Mehdi
Iran, Tehran
Digestive Diseases Research Center
Malekshah, A. F.
Iran, Tehran
Digestive Diseases Research Center
Rakhshani, N.
Iran, Tehran
Digestive Diseases Research Center
Salahi, R.
Iran, Gorgan
Golestan University of Medical Sciences
Yoonessi, A.
Iran, Tehran
Digestive Diseases Research Center
Semnani, S.
Iran, Gorgan
Golestan University of Medical Sciences
Islami, Farhad
Iran, Tehran
Digestive Diseases Research Center
Sotoudeh, M.
Iran, Tehran
Digestive Diseases Research Center
Fahimi, Saman
Iran, Tehran
Digestive Diseases Research Center
France, Lyon
Centre International de Recherche Sur le Cancer
Sadjadi, Alireza Reza
Iran, Tehran
Digestive Diseases Research Center
Nasrollahzadeh, Dariush
Iran, Tehran
Digestive Diseases Research Center
Aghcheli, K.
Iran, Tehran
Digestive Diseases Research Center
Kamangar, Farin
United States, Rockville
National Cancer Institute Nci
Abnet, Christian C.
United States, Rockville
National Cancer Institute Nci
Saidi, F.
Iran, Tehran
Digestive Diseases Research Center
Sewram, Vikash
South Africa, Tygerberg
South African Medical Research Council
Strickland, Paul T.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Dawsey, Sanford M.
United States, Rockville
National Cancer Institute Nci
Brennan, Paul J.
France, Lyon
Centre International de Recherche Sur le Cancer
Boffetta, Paolo A.
France, Lyon
Centre International de Recherche Sur le Cancer
Malekzadeh, Reza
Iran, Tehran
Digestive Diseases Research Center
Statistics
Citations: 107
Authors: 23
Affiliations: 6
Identifiers
Doi:
10.1038/sj.bjc.6602249
Research Areas
Cancer
Substance Abuse
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Male
Female