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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response
Journal of Immunology, Volume 174, No. 12, Year 2005
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Description
Mutational escape from the CTL response represents a major driving force for viral diversification in HIV-1-infected adults, but escape during infancy has not been described previously. We studied the immune response of perinatally infected children to an epitope (B57-TW10) that is targeted early during acute HIV-1 infection in adults expressing HLA-B57 and rapidly mutates under this selection pressure. Viral sequencing revealed the universal presence of escape mutations within TW10 among B57- and B5801-positive children. Mutations in TW10 and other B57-restricted epitopes arose early following perinatal infection of B57-positive children born to B57-negative mothers. Surprisingly, the majority of B57/5801-positive children exhibited a robust response to the TW10 escape variant while recognizing the wild-type epitope weakly or not at all. These data demonstrate that children, even during the first years of life, are able to mount functional immune responses of sufficient potency to drive immune escape. Moreover, our data suggest that the consequences of immune escape may differ during infancy because most children mount a strong variant-specific immune response following escape, which is rarely seen in adults. Taken together, these findings indicate that the developing immune system of children may exhibit greater plasticity in responding to a continually evolving chronic viral infection. Copyright © 2005 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Feeney, Margaret E.
United States, Boston
Harvard Medical School
United States, Boston
Boston Children's Hospital
Tang, Yanhua
United States, Boston
Harvard Medical School
Pfafferott, Katja J.
United Kingdom, Oxford
Nuffield Department of Medicine
Draenert, Rika
United States, Boston
Harvard Medical School
Trocha, Alicja K.
United States, Boston
Harvard Medical School
Yu, Xu G.
United States, Boston
Harvard Medical School
Verrill, Cori L.
United States, Boston
Harvard Medical School
Allen, Todd M.
United States, Boston
Harvard Medical School
Moore, Corey B.
Australia, Perth
Royal Perth Hospital
Mallal, Simon Alexander
Australia, Perth
Royal Perth Hospital
Burchett, Sandra K.
United States, Boston
Boston Children's Hospital
McIntosh, Kenneth
United States, Boston
Boston Children's Hospital
Pelton, Stephen Ira
United States, Boston
Boston Medical Center
St.John, M. Anne
Barbados, Bridgetown
Queen Elizabeth Hospital Bridgetown
Hazra, Rohan
United States, Rockville
National Cancer Institute Nci
Klenerman, Paul
United Kingdom, Oxford
Nuffield Department of Medicine
Altfeld, Marcus A.
United States, Boston
Harvard Medical School
Walker, Bruce D.
United States, Boston
Harvard Medical School
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
Nuffield Department of Medicine
Statistics
Citations: 96
Authors: 19
Affiliations: 7
Identifiers
Doi:
10.4049/jimmunol.174.12.7524
ISSN:
00221767
Research Areas
Infectious Diseases
Maternal And Child Health