Five-year visual results of intravitreal bevacizumab in refractory inflammatory ocular neovascularization

Purpose: To assess the 5-year visual outcome of intravitreal bevacizumab in inflammatory ocular neovascularization. Methods: Retrospective, multicenter, consecutive case series of eight patients with inflammatory ocular neovascularization refractory to standard therapy who were treated with intravitreal bevacizumab and followed for 5 years after first injection. The outcome measures included improvement of best-corrected visual acuity expressed as logarithm of minimum angle of resolution. Results: Mean best-corrected visual acuity significantly improved from 0.58 at baseline (6/23 or 20/76; standard deviation=0.32) to 0.20 at final assessment (6/10 or 20/32; standard deviation=0.25) (n=8; P=0.02), a gain of 3.8 lines (median: three injections; eight eyes; eight patients). No ocular or systemic complications from intravitreal bevacizumab were noted. Conclusion: At 5 years, intravitreal bevacizumab sustained significant visual improvement in ocular neovascularization due to a variety of inflammatory ocular diseases without major complications after a median of three injections. © 2012 Mansour et al, publisher and licensee Dove Medical Press Ltd.