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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Efficacy of hepatitis B vaccine in the Gambian expanded programme on immunisation
The Lancet, Volume 341, No. 8853, Year 1993
Notification
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Description
Because of the high prevalence of hepatitis B virus (HBV) infection in The Gambia, HBV vaccination has been incorporated into the national expanded programme on immunisation. We have assessed the efficacy of the vaccine against HBV infection and chronic carriage by examining 720 3-4-year-old children who had received the vaccine in infancy and 816 who had not received it. The vaccine was 84% (95% Cl 78-89%) effective against infection and 94% (84-98%) effective against chronic carriage. Vaccinated infants of mothers positive for hepatitis B surface and e antigens were at greater risk of breakthrough infection and chronic carriage than infants of uninfected mothers. The high vaccine efficacy against the HBV carrier state, the main risk factor for the development of chronic liver disease and liver cancer, offers hope that the prevalence of these diseases may be reduced in the future. © 1993.
Authors & Co-Authors
Fortuin, Marijke
Unknown Affiliation
Chotard, Jacques
Unknown Affiliation
Jack, Abdoulie D.
Unknown Affiliation
Maine, Nicholas P.
Unknown Affiliation
Mendy, Maimuna E.
Unknown Affiliation
Hall, Andrew J.
Unknown Affiliation
Inskip, Hazel M.
Unknown Affiliation
George, M.
Unknown Affiliation
Whittle, Hilton C.
Unknown Affiliation
Statistics
Citations: 95
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1016/0140-6736(93)93137-P
ISSN:
01406736
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Gambia