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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Essential role of collagens for terminal differentiation of preadipocytes
Biochemical and Biophysical Research Communications, Volume 187, No. 3, Year 1992
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Description
In order to study the role of collagens in the differentiation of TA1 preadipose cells in vitro, ethyl-3,4-dihydroxybenzoate (EDHB) was used as a specific inhibitor of collagen synthesis. The secretion of collagenous proteins only was severely decreased after exposure to EDHB, and this was accompanied by a decrease of differentiation as indicated by low activity levels of glycerophosphate dehydrogenase. The effect of EDHB was dose-dependent and also dependent upon the stage of cell differentiation. Northern-blot analysis show that EDHB addition to undifferentiated cells did not prevent the induction of A2COL6 gene, a marker of the preadipose state, but prevented the induction of the gene encoding for the adipocyte lipid binding protein and the modulation of the expression of the lipoprotein lipase gene which are both indicators of the adipose state. These results demonstrate that differentiation of preadipose cells into adipose cells requires active synthesis of collagens during the preadipose state. © 1992.
Authors & Co-Authors
Ibrahimi, Azeddine
France, Nice
Institut de Biologie Valrose
Statistics
Citations: 40
Authors: 1
Affiliations: 1
Identifiers
Doi:
10.1016/0006-291X(92)90446-R
ISSN:
0006291X
Research Areas
Genetics And Genomics