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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Pyrethroid resistance in Anopheles gambiae from the rubber cultivated area of Niete, South Region of Cameroon
Acta Tropica, Volume 124, No. 3, Year 2012
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Description
Anti-vector intervention remains the most effective way of controlling malaria. Although in Cameroon and elsewhere focus is on the use of long-lasting insecticidal nets and indoor residual spraying, the efficacy of both methods greatly depends on the continuing susceptibility of the vectors to the insecticides used. The emergence and spread of insecticide resistance in the major malaria vectors constitute a huge challenge to control programmes. Consequently, routine monitoring and evaluation of vector resistance status to insecticides are mandatory for early detection of resistance should it arise, and effectively planning future anti-vector interventions especially in areas reputed for routine application in agriculture. The WHO bioassay kit was used to determine the susceptibility status of Anopheles gambiae s.l. populations to seven insecticides belonging to four classes (organochlorine, organophosphate, carbamate and pyrethroids) in Niete, an area of intense rubber cultivation in southern forested Cameroon. Species and molecular forms of An. gambiae s.l. as well as the presence of knock down resistance (kdr) mutations were determined using polymerase chain reaction (PCR) techniques. All Anopheles tested was identified as An. gambiae s.s. and of the M molecular form. Based on WHO classification, while the mosquitoes were fully (100%) susceptible to malathion and bendiocarb, resistance was confirmed to DDT and the pyrethroids, permethrin and lambda-cyhalothrin. The other pyrethroids (deltamethrin and cyfluthrin) showed signs of developing resistance. Resistance to DDT and pyrethroids is indicative of existing cross resistance mechanisms between these insecticides. The increase in knockdown times was greater than twofold that of the reference susceptible strain, suggesting the possible involvement of kdr mutations, also confirmed in this study. The findings highlight the need for constant evaluation, re-evaluation and monitoring of the insecticides for malaria vector control in Cameroon. However, bendiocarb and malathion can be used and may require alternation or combination with insecticides of other classes to better manage the occurrence and spread of resistance in Niete. © 2012 Elsevier B.V.
Authors & Co-Authors
Bigoga, Jude Daiga
Cameroon, Yaounde
Biotechnology Centre
Cameroon, Yaounde
Université de Yaoundé I
Ndangoh, Derek N.
Cameroon, Yaounde
Université de Yaoundé I
Awono-Ambéné, Parfait Herman
Cameroon, Yaounde
Organisation de Coordination Pour la Lutte Contre Les Endemies
Patchoké, Salomon
Cameroon, Yaounde
Ministry of Public Health Cameroon
Fondjo, Etienne
Cameroon, Yaounde
Ministry of Public Health Cameroon
Léké, Rose Gana Fomban
Cameroon, Yaounde
Biotechnology Centre
Cameroon, Yaounde
Université de Yaoundé I
Statistics
Citations: 29
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.actatropica.2012.08.010
ISSN:
0001706X
e-ISSN:
18736254
Research Areas
Infectious Diseases
Study Design
Randomised Control Trial
Study Locations
Cameroon