Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Maternal exposure to perfluoroalkyl acids measured in whole blood and birth outcomes in offspring
Science of the Total Environment, Volume 569-570, Year 2016
Notification
URL copied to clipboard!
Description
Perfluoralkyl and polyfluoralkyl substances have been measured in plasma and serum of pregnant women as a measure of prenatal exposure. Increased concentrations of individual perfluoroalkyl acids (PFAAs), (typically perfluorooctanoic acid (PFOA) and perfluoroctane sulfonate (PFOS) have been reported to be associated with reductions in birth weight and other birth outcomes. We undertook a study of 14 PFAAs in whole blood (including PFOS, PFHxS, PFHpA, PFOA, PFNA, PFDA and PFUnDA) from 98 pregnant women in Western Australia from 2008 to 2011. Median concentrations (in μg/L) were: PFOS 1.99; PFHxS 0.33; PFOA 0.86; PFNA 0.30; PFDA 0.12 and PFUnDA 0.08. Infants born to women with the highest tertile of PFHxS exposure had an increased odds of being < 95% of their optimal birth weight (OR 3.5, 95% CI 1.1–11.5). Conversely, maternal blood concentrations of PFUnDA were associated with non-significant increases in average birth weight (+ 102 g, 95% CI − 41, 245) and significant increases in proportion of optimal birth weight (+ 4.7%, 95% CI 0.7, 8.8) per ln-unit change. This study has reported a range of PFAAs in the whole blood of pregnant women and suggests that PFHxS and PFUnDA may influence foetal growth and warrant further attention. Additional studies are required to identify the sources of PFAA exposure with a view to prevention, in addition to further studies investigating the long term health effects of these ubiquitous chemicals. © 2016
Authors & Co-Authors
Callan, Anna Carita
Australia, Perth
Edith Cowan University
Heyworth, Jane Shirley
Australia, Perth
The University of Western Australia
Mueller, Jochen F.
Australia, Woolloongabba
Queensland Alliance for Environmental Health Sciences
Odland, Jon Øyvind
Norway, Tromso
Uit Norges Arktiske Universitet
Hinwood, Andrea Lee
Australia, Perth
Edith Cowan University
Statistics
Citations: 38
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1016/j.scitotenv.2016.06.177
ISSN:
00489697
Research Areas
Maternal And Child Health
Participants Gender
Female