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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Biomarker evaluation of self-reported condom use among women in HIV-discordant couples
International Journal of STD and AIDS, Volume 24, No. 7, Year 2013
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Description
Self-reported condom use is a commonly collected statistic, yet its use in research studies may be inaccurate. We evaluated this statistic among women in HIV-discordant couples enrolled in a clinical trial in Nairobi, Kenya. Vaginal swabs were acquired from 125 women and tested for prostate-specific antigen (PSA), a biomarker for semen exposure, using an enzyme-linked immunosorbent assay. Ten (10%) of 98 women who reported 100% use of condoms in the previous month tested PSA positive. In a bivariate logistic regression analysis, among women who reported 100% condom use in the previous month, those with ≤8 years of school had significantly higher odds of testing PSA-positive (odds ratio [OR] = 8.39, 95% confidence interval [CI] 1.02-69.13) than women with more schooling. Our estimate may be conservative, as the ability to detect PSA may be limited to 24-48 hours after exposure. Less educated women may be a target group for counselling regarding reporting sexual behaviour in clinical trials. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
Authors & Co-Authors
Mose, F.
Kenya, Nairobi
University of Nairobi
Newman, Laura P.
United States, Seattle
University of Washington
Njunguna, R.
Kenya, Nairobi
University of Nairobi
Tamooh, Harrison
Kenya, Nairobi
University of Nairobi
John-Stewart, Grace C.
United States, Seattle
University of Washington
Farquhar, Carey
United States, Seattle
University of Washington
Kiarie, James Njogu
Kenya, Nairobi
University of Nairobi
Statistics
Citations: 15
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1177/0956462412473892
ISSN:
09564624
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Study Design
Case-Control Study
Study Approach
Quantitative
Study Locations
Kenya
Participants Gender
Female