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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Antimicrobial antioxidant daucane sesquiterpenes from Ferula hermonis Boiss
Phytotherapy Research, Volume 26, No. 4, Year 2012
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Description
Seventeen daucane sesquiterpenoid esters, including a new one (4), were isolated from the root of Ferula hermonis Boiss. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidence and correlated with known compounds. The relative stereochemistry of the new compound was determined using 2D NOESY and the most stable and the lowest energy conformation was determined using molecular modelling. The antimicrobial activity was evaluated by determination of MIC using the broth microdilution method against six bacterial strains and one fungal strain (Pseudomonas aeruginosa PAO1, Escherichia coli, Bacillus subtilis ATCC6633, Mycobacterium bovis BCG Pasteur, Mycobacterium tuberculosis H37Rv, Staphylococcus aureus ATCC6538 and Candida albicans SC5314). There was a significant indication that compounds 15, 16, 17 demonstrated potent activity against Gram +ve (S. aureus, B. subtilis), as well as Mycobacterium strains M. bovis BCG and M. tuberculosis H37Rv. None of the isolated compounds exhibited a significant antifungal activity. In the antioxidant study using the DPPH assay method, the highest radical scavenging activity was observed for compounds 15, 16, 17. Copyright © 2011 John Wiley & Sons, Ltd.
Authors & Co-Authors
Ibraheim, Zedan Zeid
Egypt, Asyut
Faculty of Pharmacy
Abdel-Mageed, Wael M.
Egypt, Asyut
Faculty of Pharmacy
Dai, Huanqin
China, Beijing
Institute of Microbiology Chinese Academy of Sciences
Guo, Hui
China, Beijing
Institute of Microbiology Chinese Academy of Sciences
Zhang, Lixin
China, Beijing
Institute of Microbiology Chinese Academy of Sciences
Jaspars, Marcel
United Kingdom, Aberdeen
University of Aberdeen
Statistics
Citations: 60
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1002/ptr.3609
ISSN:
0951418X
e-ISSN:
10991573