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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The Childhood Leukemia International Consortium
Cancer Epidemiology, Volume 37, No. 3, Year 2013
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Description
Background: Acute leukemia is the most common cancer in children under 15 years of age; 80% are acute lymphoblastic leukemia (ALL) and 17% are acute myeloid leukemia (AML). Childhood leukemia shows further diversity based on cytogenetic and molecular characteristics, which may relate to distinct etiologies. Case-control studies conducted worldwide, particularly of ALL, have collected a wealth of data on potential risk factors and in some studies, biospecimens. There is growing evidence for the role of infectious/immunologic factors, fetal growth, and several environmental factors in the etiology of childhood ALL. The risk of childhood leukemia, like other complex diseases, is likely to be influenced both by independent and interactive effects of genes and environmental exposures. While some studies have analyzed the role of genetic variants, few have been sufficiently powered to investigate gene-environment interactions. Objectives: The Childhood Leukemia International Consortium (CLIC) was established in 2007 to promote investigations of rarer exposures, gene-environment interactions and subtype-specific associations through the pooling of data from independent studies. Methods: By September 2012, CLIC included 22 studies (recruitment period: 1962-present) from 12 countries, totaling approximately 31. 000 cases and 50. 000 controls. Of these, 19 case-control studies have collected detailed epidemiologic data, and DNA samples have been collected from children and child-parent trios in 15 and 13 of these studies, respectively. Two registry-based studies and one study comprising hospital records routinely obtained at birth and/or diagnosis have limited interview data or biospecimens. Conclusions: CLIC provides a unique opportunity to fill gaps in knowledge about the role of environmental and genetic risk factors, critical windows of exposure, the effects of gene-environment interactions and associations among specific leukemia subtypes in different ethnic groups. © 2013 Elsevier Ltd.
Authors & Co-Authors
Metayer, Catherine
United States, Berkeley
University of California, Berkeley
Milne, Elizabeth
Australia, Perth
Telethon Kids Institute
Clavel, Jacqueline
France, Paris
Inserm
Infante-Rivard, Claire I.r.c.
Canada, Montreal
Mcgill Faculty of Medicine and Health Sciences
Petridou, Th Eleni
Greece, Athens
School of Medicine
Taylor, Gordon Malcolm
United Kingdom, Manchester
The University of Manchester
Schüz, Joachim
France, Lyon
Centre International de Recherche Sur le Cancer
Spector, Logan G.
United States, Minneapolis
Masonic Cancer Center
Dockerty, John D.
New Zealand, Dunedin
Otago Medical School
Magnani, Corrado
Italy, Novara
Scuola Di Medicina
Pombo-de-Oliveira, Maria S.
Brazil, Rio de Janeiro
Instituto Nacional de Cancer
Sinnett, Daniel
Canada, Montreal
Chu Sainte-justine - le Centre Hospitalier Universitaire Mère-enfant
Murphy, Michael F.G.
United Kingdom, Oxford
University of Oxford
Roman, Eve A.
United Kingdom, York
University of York
Monge, Patricia
Costa Rica, Heredia
Universidad Nacional
Ezzat, Sameera
Egypt, Cairo
Children's Cancer Hospital 57357
Egypt, Shibin el Kom
Menoufia University
Mueller, Beth A.
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Scheurer, Michael E.
United States, Houston
Baylor College of Medicine
United States, Houston
Texas Children's Cancer Center and Hematology Service
Armstrong, Bruce Konrad
Australia, Sydney
The University of Sydney School of Public Health
Birch, Jillian M.
United Kingdom, Manchester
The University of Manchester
Kaatsch, Peter
Germany, Mainz
Johannes Gutenberg-universität Mainz
Koifman, Sérgio
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Lightfoot, Tracy
United Kingdom, York
University of York
Bhatti, Parveen
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Bondy, Melissa L.
United States, Houston
Baylor College of Medicine
United States, Houston
Texas Children's Cancer Center and Hematology Service
Rudant, Jérémie
United Kingdom, Manchester
The University of Manchester
O'Neill, Kate A.
United Kingdom, Oxford
University of Oxford
Miligi, Lucia
Italy, Florence
Cancer Prevention and Research Institute Ispo
Dessypris, Nick
Greece, Athens
School of Medicine
Kang, Alice Y.
United States, Berkeley
University of California, Berkeley
Buffler, Patricia A.
United States, Berkeley
University of California, Berkeley
Statistics
Citations: 100
Authors: 31
Affiliations: 25
Identifiers
Doi:
10.1016/j.canep.2012.12.011
ISSN:
18777821
e-ISSN:
1877783X
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Study Design
Case-Control Study