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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19
Nature Communications, Volume 11, No. 1, Article 5703, Year 2020
Notification
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Description
Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptomatic infections, but the underlying immunological differences remain unclear. Here, we describe clinical features, virology, longitudinal cellular, and cytokine immune profile, SARS-CoV-2-specific serology and salivary antibody responses in a family of two parents with PCR-confirmed symptomatic SARS-CoV-2 infection and their three children, who tested repeatedly SARS-CoV-2 PCR negative. Cellular immune profiles and cytokine responses of all children are similar to their parents at all timepoints. All family members have salivary anti-SARS-CoV-2 antibodies detected, predominantly IgA, that coincide with symptom resolution in 3 of 4 symptomatic members. Plasma from both parents and one child have IgG antibody against the S1 protein and virus-neutralizing activity detected. Using a systems serology approach, we demonstrate higher levels of SARS-CoV-2-specific antibody features of these family members compared to healthy controls. These data indicate that children can mount an immune response to SARS-CoV-2 without virological confirmation of infection, raising the possibility that immunity in children can prevent the establishment of SARS-CoV-2 infection. Relying on routine virological and serological testing may not identify exposed children, with implications for epidemiological and clinical studies across the life-span. © 2020, The Author(s).
Authors & Co-Authors
Do, Lien Anh Ha
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Donato, Celeste M.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Flanagan, Katie L.
Australia, Launceston
Launceston General Hospital
Australia, Hobart
University of Tasmania
Australia, Clayton
Monash University
Australia, Melbourne
Rmit University
Arnold, Kelly B.
United States, Ann Arbor
University of Michigan, Ann Arbor
Mulholland, Edward Kim
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Bines, Julie E.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Pellicci, Daniel G.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Curtis, Nigel C.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Steer, Andrew C.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Saffery, Richard
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Subbarao, Kanta
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Australia, Canberra
World Health Organization, Australia
Chung, Amy W.
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Kedzierska, Katherine
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Burgner, David Paul
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Crawford, Nigel W.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Statistics
Citations: 70
Authors: 15
Affiliations: 11
Identifiers
Doi:
10.1038/s41467-020-19545-8
ISSN:
20411723
Research Areas
Covid
Maternal And Child Health
Study Design
Cohort Study