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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
All T15 Id-positive antibodies (but not the majority of VHT15+ antibodies) are produced by peritoneal CD5+ B lymphocytes
International Immunology, Volume 2, No. 6, Year 1990
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Description
After adult irradiation and reconstitutlon with autologous bone marrow, BALB/c and C.B20 mice no longer utilize the T15 Id In response to phosphorylchollne. T15 Id expression can be restored by transfers of peritoneal B cells or by FACS-purlfled CD5+ IgM+ lymphocytes (but not by T lymphocytes) from syngenelc donors. Using bone marrow and peritoneal cell donors that are congeneic for heavy and light chain allotypes, the exclusive origin of the T15 Id In peritoneal B cells was ascertained. These conclusions have been essentially confirmed by Immunization with either antl-T15 Id or antl-VHT15 antibodies conjugated to llpopolysaccharlde. Thus, the production of VHT15-positlve antibodies continues at control levels In bone marrow-reconstituted animals while no T15 Id production can be stimulated even In this protocol of direct B cell stimulation. These results constitute the first formal demonstration of the exclusive production of an Id by CD5+ B-cells. © 1990 Oxford University Press.
Authors & Co-Authors
Masmoudi, Hatem
France, Paris
Institut Pasteur, Paris
Huetz, François
France, Paris
Institut Pasteur, Paris
Coutinho, A. A.
France, Paris
Institut Pasteur, Paris
Cazenave, Pierre André
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 187
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1093/intimm/2.6.515
ISSN:
09538178
Research Areas
Maternal And Child Health