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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Susceptibility to malaria in fulani, Bariba, Otamari and gando individuals living in sympatry in Benin: Role of opsonizing antibodies to Plasmodium falciparum merozoites
Heliyon, Volume 9, No. 1, Article e13092, Year 2023
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Description
Objectives: Fulani in Africa are known to be less susceptible to Plasmodium falciparum (Pf) malaria. This study explored a potential involvement of antibody-mediated merozoite phagocytosis mechanism in this natural protection against malaria. Methods: Before the start of the malaria transmission season (MTS) in Benin, the functionality of antibodies against Pf merozoites was determined by the opsonic phagocytosis (OP) assay in plasma samples from Fulani, Bariba, Otamari and Gando groups. These individuals were actively followed-up for malaria detection from the beginning to the end of MTS. Anti-GLURP Immunoglobulin G antibody quantification, malaria Rapid Diagnostic Test (RDT) and spleen palpation were performed before and after MTS. Results: In Bariba, Otamari and Gando, but not in Fulani, plasma from adults promoted higher levels of OP than the children (P = 0.003; P = 0.012; P = 0.031 and P = 0.122). A high proportion of Fulani children had higher OP and anti-GLURP (P < 0.0001) antibody levels as compared to non-Fulani children; whereas this was not observed for Fulani adults (P = 0.223). High OP levels before MTS were significantly related to negative RDT after MTS (P = 0.011). Conclusion: Our results highlight the ability of opsonizing antibodies to potentially enhance natural protection of young Fulani individuals against Pf malaria in Benin. © 2023 The Authors
Authors & Co-Authors
Fall, Abdou Khadre Dit Jadir
France, Marseille
Ird Institut de Recherche Pour le Developpement
Kana, Ikhlaq Hussain
Denmark, Copenhagen
Statens Serum Institut
Denmark, Copenhagen
Københavns Universitet
Garcia-Senosiain, Asier
Denmark, Copenhagen
Statens Serum Institut
Denmark, Copenhagen
Københavns Universitet
Henry, Benoît
France, Paris
Inserm
Dechavanne, Célia
France, Marseille
Ird Institut de Recherche Pour le Developpement
Garcia, André
France, Marseille
Ird Institut de Recherche Pour le Developpement
Buffet, Pierre A.
France, Paris
Inserm
France, Paris
Institut Pasteur, Paris
Sabbagh, Audrey
France, Marseille
Ird Institut de Recherche Pour le Developpement
Migot-Nabias, Florence
France, Marseille
Ird Institut de Recherche Pour le Developpement
Theisen, Michael
Denmark, Copenhagen
Statens Serum Institut
Denmark, Copenhagen
Københavns Universitet
Courtin, David
France, Marseille
Ird Institut de Recherche Pour le Developpement
Statistics
Citations: 1
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1016/j.heliyon.2023.e13092
ISSN:
24058440
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Benin