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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Childhood cancer and residential exposure to highways: a nationwide cohort study
European Journal of Epidemiology, Volume 30, No. 12, Year 2015
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Description
Children living near highways are exposed to higher concentrations of traffic-related carcinogenic pollutants. Several studies reported an increased risk of childhood cancer associated with traffic exposure, but the published evidence is inconclusive. We investigated whether cancer risk is associated with proximity of residence to highways in a nation-wide cohort study including all children aged <16 years from Swiss national censuses in 1990 and 2000. Cancer incidence was investigated in time to event analyses (1990–2008) using Cox proportional hazards models and incidence density analyses (1985–2008) using Poisson regression. Adjustments were made for socio-economic factors, ionising background radiation and electromagnetic fields. In time to event analysis based on 532 cases the adjusted hazard ratio for leukaemia comparing children living <100 m from a highway with unexposed children (≥500 m) was 1.43 (95 % CI 0.79, 2.61). Results were similar in incidence density analysis including 1367 leukaemia cases (incidence rate ratio (IRR) 1.57; 95 % CI 1.09, 2.25). Associations were similar for acute lymphoblastic leukaemia (IRR 1.64; 95 % CI 1.10, 2.43) and stronger for leukaemia in children aged <5 years (IRR 1.92; 95 % CI 1.22, 3.04). Little evidence of association was found for other tumours. Our study suggests that young children living close to highways are at increased risk of developing leukaemia. © 2015, Springer Science+Business Media Dordrecht.
Authors & Co-Authors
Daniel Spycher, Ben Daniel
Switzerland, Bern
University of Bern
Feller, Martin
Switzerland, Bern
University of Bern
Switzerland, Bern
University Hospital Bern
Röösli, Martin
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
Ammann, Roland A.
Switzerland, Bern
University of Bern
Diezi, Manuel
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Egger, Matthias
Switzerland, Bern
University of Bern
Kuehni, Claudia E.
Switzerland, Bern
University of Bern
Statistics
Citations: 39
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1007/s10654-015-0091-9
ISSN:
03932990
Research Areas
Cancer
Environmental
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative