Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Identification and predictive value of interleukin-6+ interleukin-10+ and interleukin-6-interleukin-10+ cytokine patterns in st-elevation acute myocardial infarction
Circulation Research, Volume 111, No. 10, Year 2012
Notification
URL copied to clipboard!
Description
RATIONALE: At the onset of ST-elevation acute myocardial infarction (STEMI), patients can present with very high circulating interleukin-6 (IL-6) levels or very low-IL-6 levels. OBJECTIVE: We compared these 2 groups of patients to understand whether it is possible to define specific STEMI phenotypes associated with outcome based on the cytokine response. METHODS AND RESULTS: We compared 109 patients with STEMI in the top IL-6 level (median, 15.6 pg/mL; IL-6 STEMI) with 96 in the bottom IL-6 level (median, 1.7 pg/mL; IL-6 STEMI) and 103 matched controls extracted from the multiethnic First Acute Myocardial Infarction study. We found minimal clinical differences between IL-6 STEMI and IL-6 STEMI. We assessed the inflammatory profiles of the 2 STEMI groups and the controls by measuring 18 cytokines in blood samples. We exploited clustering analysis algorithms to infer the functional modules of interacting cytokines. IL-6 STEMI patients were characterized by the activation of 2 modules of interacting signals comprising IL-10, IL-8, macrophage inflammatory protein-1α, and C-reactive protein, and monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, and monokine induced by interferon-γ. IL-10 was increased both in IL-6 STEMI and IL-6 STEMI patients compared with controls. IL-6IL-10 STEMI patients had an increased risk of systolic dysfunction at discharge and an increased risk of death at 6 months in comparison with IL-6IL-10 STEMI patients. We combined IL-10 and monokine induced by interferon-γ (derived from the 2 identified cytokine modules) with IL-6 in a formula yielding a risk index that outperformed any single cytokine in the prediction of systolic dysfunction and death. CONCLUSIONS: We have identified a characteristic circulating inflammatory cytokine pattern in STEMI patients, which is not related to the extent of myocardial damage. The simultaneous elevation of IL-6 and IL-10 levels distinguishes STEMI patients with worse clinical outcomes from other STEMI patients. These observations could have potential implications for risk-oriented patient stratification and immune-modulating therapies. © 2012 American Heart Association, Inc.
Authors & Co-Authors
Ammirati, Enrico
Italy, Milan
Università Vita-salute San Raffaele
Italy, Milan
Asst Grande Ospedale Metropolitano Niguarda
Italy, Florence
Associazione Nazionale Medici Cardiologi Ospedalieri
Cannistraci, Carlo Vittorio
Italy, Milan
Università Vita-salute San Raffaele
Italy, Turin
Politecnico Di Torino
United States, La Jolla
University of California, San Diego
Saudi Arabia, Thuwal
King Abdullah University of Science and Technology
Cristell, Nicole A.
Italy, Milan
Università Vita-salute San Raffaele
Vecchio, Viviana
Italy, Milan
Università Vita-salute San Raffaele
Palini, Alessio G.
Italy, Milan
Università Vita-salute San Raffaele
Tornvall, Per
Sweden, Stockholm
Karolinska Institutet
Paganoni, Anna Maria
Italy, Milan
Politecnico Di Milano
Miendlarzewska, Ewa A.
Switzerland, Geneva
Université de Genève
Sangalli, Laura M.
Italy, Milan
Politecnico Di Milano
Monello, Alberto
Italy, Milan
Università Vita-salute San Raffaele
Pernow, John
Sweden, Stockholm
Karolinska Institutet
Björnstedt Bennermo, Marie
Sweden, Danderyd
Danderyds Sjukhus
Marenzi, Giancarlo
Italy, Milan
Università Degli Studi Di Milano
Hu, Dayi
China, Beijing
Peking University People's Hospital
Uren, Neal G.
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Cianflone, Domenico
Italy, Milan
Università Vita-salute San Raffaele
Ravasi, Timothy
United States, La Jolla
University of California, San Diego
Saudi Arabia, Thuwal
King Abdullah University of Science and Technology
Manfredi, Angelo A.
Italy, Milan
Università Vita-salute San Raffaele
Maseri, Attilio
Italy, Florence
Associazione Nazionale Medici Cardiologi Ospedalieri
Statistics
Citations: 71
Authors: 19
Affiliations: 13
Identifiers
Doi:
10.1161/CIRCRESAHA.111.262477
e-ISSN:
15244571
Research Areas
Health System And Policy